Investigator Initiated Research (IIR)

EVICR.net is a platform for multinational clinical research in Ophthalmology in Europe and a structure to support multinational Investigator-Initiated Research (IIR). IIR are studies instigated by academic researchers.

If you are an Investigator and you have an idea for a multinational clinical study, EVICR.net helps you to develop your idea in a clinical research study in ophthalmology.

Consult the EVICR.net Investigator Initiated Research (IIR) leaflet for further information.


Ongoing Investigator Initiated Research

 

1.EudraCT nº 2012-001200-38
ClinicalTrials.gov nº NCT01726075

EUROCONDOR – Neurodegeneration as an early event in the pathogenesis of Diabetic Retinopathy: A multicentric, prospective, phase II-III, double-blind randomized controlled trial to assess the efficacy of neuroprotective drugs administered topically to prevent or arrest Diabetic Retinopathy

Project Coordinator: Rafael Simó, Barcelona, Spain

Coordinating Investigator: José Cunha-Vaz, Coimbra, Portugal (CS1)

Participating Centres (11): Barcelona, Birmingham, Cheltenham, Coimbra, Liverpool, London, Milan, Odense, Padova, Paris, Ulm

Financial Support: European Union 7th Framework Programme – Call Health 2011 – Project nº 278040-2

 

2.EudraCT nº 2014-000239-18

STRONG – European Consortium for the Study of a Topical Treatment of Neovascular Glaucoma

Protocol nº GS-101-P1-NVR

Project Coordinator: Norbert Pfeiffer, Mainz, Germany (CS2)

Participating Centres (35): Albacete, Alicante, Barcelona (3), Bonn, Chieti, Coimbra, Dusseldorf, Freiburg, Giessen, Gottingen, Hannover, Koln, Lisbon, Liverpool, London (2), Mainz, Milan, Parma, Porto, Surrey, Tuebingen, Valencia. Others to be selected.

Financial Support: European Union 7th Framework Programme – Call Health 2012 – Project nº 30532

 

3.EudraCT nº 2013-003640-23

ClinicalTrials.gov nº NCT01941329

PROTEUS – Prospective, randomized, multicenter, open label, phase II / III study to assess efficacy and safety of ranibizumab 0.5 mg intravitreal injections plus panretinal photocoagulation (PRP) versus PRP in monotherapy in the treatment of subjects with high risk proliferative diabetic retinopathy

Coordinating Investigator: João Figueira, Coimbra, Portugal (CS1)

Participating Centres (14): Cheltenham, Coimbra (2), Dijon, Frimely, Lisbon, London, Milan (2), Padova, Paris (2), Rome, Vila Franca de Xira

IIR Grant: Novartis

 

4. ClinicalTrials.gov nº NCT02121197

ARTES – A Collaborative Retrospective Trial on the Efficacy and Safety of intravitreal dexamethasone implant (Ozurdex) in patients with Diabetic Macular Edema (DME). The European DME Register Study

Protocol nº ECR-RET-2014-07

Coordinating Investigator: Anat Loewenstein, Tel Aviv, Israel (CS60)

Participating Centres (25): Avignon, Barcelona (4), Bari, Chieti, Coimbra, Frimely, Kuopio, London, Lyon, Madrid, Marseille, Milan, Padova, Paris (2), Rehovot, Rome, Stockholm, Tel Aviv, Udine, Valencia

IIR Grant: Allergan

 

5. ClinicalTrials.gov nº NCT02495181

EudraCT nº 2015-001368-20

ATLANTIC – A Randomized, Double-masked, Sham-controlled Phase 4 Study of the Efficacy, Safety, and Tolerability of Intravitreal Aflibercept Monotherapy Compared to Aflibercept with Adjunctive Photodynamic Therapy in patients with Polypoidal Choroidal Vasculopathy

Coordinating Investigator: Rufino Silva, Coimbra, Portugal (CS82)

Participating Centres (18): Albacete, Barcelona (4), Braga, Coimbra (2), Las Palmas, Leiria, Lisbon (4), Oviedo, Porto (2), Vila Franca de Xira

IIR Grant: Bayer

 

6. ClinicalTrials.gov nº NCT03235856

REDCAKE – Retrospective Digital Computer Analysis of Keratoconus Evolution

Coordinating Investigator: Jos Rozema, Antwerp, Belgium (CS12)

Participating Centres (13): Belgium, Germany, Italy, Spain, Switzerland, Netherlands, Portugal

Sponsor: Antwerp University Hospital

IIR Grant: Flemish Fund for Research

 

7. ClinicalTrials.gov nº NCT03349801

MACUSTAR – Intermediate AMD: Development of novel clinical endpoints for clinical trials in patients with a regulatory and patient access intention

Coordinating Investigator: Frank Holz, Bonn, Germany (CS15)

Participating Centres (20): Denmark, France, Germany, Italy, Netherlands, Portugal, United Kingdom

Sponsor: University Hospital Bonn

Financial Support: IMI2 and EFPIA – Project nº 116076

 

Other ongoing Investigator Initiated Research

 

1. ClinicalTrials.gov nº NCT03297515

MADEOS – Prospective, randomised, double-blind study to assess the Therapeutic Potential of Omega-3 Fatty Acids Supplementation in Dry Macular Degeneration and Stargardt Disease (Macular Degeneration Omega-3 Study

Participating Centres (5): France (1), Germany (1), Italy (3)

Sponsor: Ophthalmos Research and Educational Institute

Positioning at the Ophthalmology Research in Europe

EVICR.net serves as a fundamental resource for the development of translational research and particularly Pharmaceutical and Medical Devices Innovation in the European Union in Ophthalmology.