Investigator Initiated Research (IIR) is a platform for multinational clinical research in Ophthalmology in Europe and a structure to support multinational Investigator-Initiated Research (IIR). IIR are studies instigated by academic researchers.

If you are an Investigator and you have an idea for a multinational clinical study, helps you to develop your idea in a clinical research study in ophthalmology.

Consult the Investigator Initiated Research (IIR) leaflet for further information.

Ongoing Investigator Initiated Research


1. nº NCT04281186

RECOGNISED –Retinal and Cognitive dysfunction in type 2 diabetes: unraveling the common pathways and identification of patients at risk of dementia

Coordinating Investigator: R. Simó, Barcelona, Spain (CS74)

Participating Centres (10): Denmark, Italy, Netherlands, Portugal, Spain and UK

Sponsor: Fundació Hospital Universitari Vall D’Hebron, VHIR, represented by Prof. Rafael Simó.

Financial Support:  Horizon 2020 – Project nº 847749


2. IRD Survey is conducting an International Survey entitled “Current management of Inherited Retinal Diseases (IRD) subjects in Europe”.

Financial Support: Novartis


3. nº NCT02495181

EudraCT nº 2015-001368-20

ATLANTIC – A Randomized, Double-masked, Sham-controlled Phase 4 Study of the Efficacy, Safety, and Tolerability of Intravitreal Aflibercept Monotherapy Compared to Aflibercept with Adjunctive Photodynamic Therapy in patients with Polypoidal Choroidal Vasculopathy

Coordinating Investigator: Rufino Silva, Coimbra, Portugal (CS82)

Participating Centres (18): Albacete, Barcelona (4), Braga, Coimbra (2), Las Palmas, Leiria, Lisbon (4), Oviedo, Porto (2), Vila Franca de Xira

IIR Grant: Bayer


4. nº NCT03235856

REDCAKE – Retrospective Digital Computer Analysis of Keratoconus Evolution

Coordinating Investigator: Jos Rozema, Antwerp, Belgium (CS12)

Participating Centres (13): Belgium, Germany, Italy, Spain, Switzerland, Netherlands, Portugal

Sponsor: Antwerp University Hospital

IIR Grant: Flemish Fund for Research


5. nº NCT03349801

MACUSTAR – Intermediate AMD: Development of novel clinical endpoints for clinical trials in patients with a regulatory and patient access intention

Coordinating Investigator: Frank Holz, Bonn, Germany (CS15)

Participating Centres (20): Denmark, France, Germany, Italy, Netherlands, Portugal, United Kingdom

Sponsor: University Hospital Bonn

Financial Support: IMI2 and EFPIA – Project nº 116076


Other ongoing Investigator Initiated Research


1. nº NCT03297515

MADEOS – Prospective, randomised, double-blind study to assess the Therapeutic Potential of Omega-3 Fatty Acids Supplementation in Dry Macular Degeneration and Stargardt Disease (Macular Degeneration Omega-3 Study)

Participating Centres (5): France (1), Germany (1), Italy (3)

Sponsor: Ophthalmos Research and Educational Institute

Positioning at the Ophthalmology Research in Europe serves as a fundamental resource for the development of translational research and particularly Pharmaceutical and Medical Devices Innovation in the European Union in Ophthalmology.